Avaliação dos níveis de IgE em amostras de urina, de pessoas com e sem rinite alérgica, coletadas em momentos distintos do dia
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Data
2018-09-11
Autores
Orientador
Hoerlle, Jairo Luís
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Resumo
INTRODUÇÃO: A rinite alérgica é uma doença que causa inflamação, obstrução das vias nasais e produção de muco, sendo desencadeada por agentes alergênicos transportados pelo ar. Os alérgenos, reagem com mastócitos, sensibilizados por IgE onde ocorre a liberação de mediadores dos mastócitos que aumentam a
permeabilidade capilar e causam vasodilatação localizada iniciando a reação imunológica que causa os sintomas. OBJETIVO: Determinar os níveis da imunoglobulina E em amostras de urina de pessoas com rinite alérgica para identificar possíveis variações deste analito durante o dia. MÉTODOS: Fizeram parte desta
pesquisa, 21 voluntários, sendo 11 que se declararam com rinite alérgica e 10 que afirmaram não ter rinite alérgica. Os voluntários responderam a um questionário para investigar dados pessoais, após, foram orientados sobre a pesquisa, na qual foi coletada três amostras de urina de cada voluntário em momentos distintos do dia. RESULTADOS: A amplitude dos valores das IgEs nas dosagens foi de 55% no período
da manhã, 42% para os valores após o almoço e 82% para os valores das 18 horas.Os dados foram comparados estatisticamente pelo Teste t, teste de Pearson, e Shapiro-Wilk. CONCLUSÃO: Os resultados deste estudo mostraram que houve pouca variação da IgE nos períodos distintos do dia, independente da condição de se ter ou não rinite e do sexo dos participantes, sendo os valores de “p” sem significância.
INTRODUCTION: Allergic rhinitis is a disease that causes inflammation, obstruction of the nasal passages and production of mucus, being triggered by airborne allergenic agents. Allergens react with mast cells, sensitized by IgE where the release of mediators from mast cells occurs that increase capillary permeability and cause localized vasodilation by initiating the immune reaction that causes the symptoms. OBJECTIVE: To determine levels of immunoglobulin E in urine samples from people with allergic rhinitis to identify variations during the day. METHODS: Twenty-one patients were included in the study, 11 of whom declared themselves with allergic rhinitis and 10 who said they did not have allergic rhinitis. The volunteers answered a questionnaire to investigate personal data, after being guided about the research, in which three urine samples were collected from each volunteer at different times of the day. RESULTS: The amplitude of the IgE values in the dosages was 55% in the morning, 42% for the values after the lunch hour and 82% for the values of the 18 hours. The data were compared statistically to Test t, test of Pearson, and Shapiro-Wilk. CONCLUSION: The results of this study showed that there was little variation of IgE in distinct periods of the day, regardless of whether or not the sex of the participants and rhinitis, the values of "p" without significance.
INTRODUCTION: Allergic rhinitis is a disease that causes inflammation, obstruction of the nasal passages and production of mucus, being triggered by airborne allergenic agents. Allergens react with mast cells, sensitized by IgE where the release of mediators from mast cells occurs that increase capillary permeability and cause localized vasodilation by initiating the immune reaction that causes the symptoms. OBJECTIVE: To determine levels of immunoglobulin E in urine samples from people with allergic rhinitis to identify variations during the day. METHODS: Twenty-one patients were included in the study, 11 of whom declared themselves with allergic rhinitis and 10 who said they did not have allergic rhinitis. The volunteers answered a questionnaire to investigate personal data, after being guided about the research, in which three urine samples were collected from each volunteer at different times of the day. RESULTS: The amplitude of the IgE values in the dosages was 55% in the morning, 42% for the values after the lunch hour and 82% for the values of the 18 hours. The data were compared statistically to Test t, test of Pearson, and Shapiro-Wilk. CONCLUSION: The results of this study showed that there was little variation of IgE in distinct periods of the day, regardless of whether or not the sex of the participants and rhinitis, the values of "p" without significance.
Descrição
Palavras-chave
Rinite Alérgica; IgE; Urina
Citação
BARBOSA, Daniele Karen Andres. Avaliação dos níveis de IgE em amostras de urina, de pessoas com e sem rinite alérgica, coletadas em momentos distintos do dia. 2018. Artigo (Graduação) – Curso de Biomedicina, Universidade do Vale do Taquari - Univates, Lajeado, 02 jul. 2018. Disponível em: http://hdl.handle.net/10737/2270.